Publikationen

Gemeinsame Publikationen der beteiligten Arbeitsgruppen im Rahmen des Leibniz-WissenschaftsCampus InterACt

2022

Boddin J, Ip WH, Wilkens B, von Stromberg K, Ching W, Koyuncu E, Bertzbach LD, Dobner T. (2022) A Single Amino Acid Switch in the Adenoviral DNA Binding Protein Abrogates Replication Center Formation and Productive Viral Infection. mBio. 2022 Mar 7:e0014422. doi: 10.1128/mbio.00144-22
Caragliano E, Bonazza S, Frascaroli G, Tang J, Soh TK, Grünewald K, Bosse JB, Brune W. (2022) Human cytomegalovirus forms phase-separated compartments at viral genomes to facilitate viral replication. Cell Reports. 2022 Mar 8. doi: 10.1016/j.celrep.2022.110469
Falter C, Reumann S. (2022) The essential role of fungal peroxisomes in plant infection. Mol Plant Pathol. 2022 Jan 10. doi: 10.1111/mpp.13180
Ivanova ME, Lukoyanova N, Malhotra S, Topf M, Trapani JA, Voskoboinik I, Saibil HR. (2022) The pore conformation of lymphocyte perforin. Sci Adv 8(6):eabk3147. doi: 10.1126/sciadv.abk3147

2021

Cook AD, Roberts AJ, Atherton J, Tewari R, Topf M, Moores CA. (2021) Cryo-EM structure of a microtubule-bound parasite kinesin motor and implications for its mechanism and inhibition. J Biol Chem 297(5):101063. doi: 10.1016/j.jbc.2021.101063
Cragnolini T, Kryshtafovych A, Topf M. Cryo-EM targets in CASP14. Proteins. 2021 Dec;89(12):1949-1958. doi: 10.1002/prot.26216
Cragnolini T, Sahota H, Joseph AP, Sweeney A, Malhotra S, Vasishtan D, Topf M. (2021) TEMPy2: a Python library with improved 3D electron microscopy density-fitting and validation workflows. Acta Crystallogr D Struct Biol 77(Pt 1):41–47. doi: 10.1107/S2059798320014928
Dülfer J, Yan H, Brodmerkel MN, Creutznacher R, Mallagaray A, Peters T, Caleman C, Marklund EG, Uetrecht C. (2021) Glycan-Induced Protein Dynamics in Human Norovirus P Dimers Depend on Virus Strain and Deamidation Status. Molecules. 2021 Apr 7;26(8):2125. doi: 10.3390/molecules26082125
Ferreira JL, Heincke D, Wichers JS, Liffner B, Wilson DW, Gilberger TW (2021). The Dynamic Roles of the Inner Membrane Complex in the Multiple Stages of the Malaria Parasite. Front Cell Infect Microbiol. 2021 Jan 8;10:611801.doi: 10.3389/fcimb.2020.611801
Günther S, Reinke PYA, Fernández-García Y, Lieske J, Lane TJ, Ginn HM, Koua FHM, Ehrt C, Ewert W, Oberthuer D, Yefanov O, Meier S, Lorenzen K, Krichel B, Kopicki JD, Gelisio L, Brehm W, Dunkel I, Seychell B, Gieseler H, Norton-Baker B, Escudero-Pérez B, Domaracky M, Saouane S, Tolstikova A, White TA, Hänle A, Groessler M, Fleckenstein H, Trost F, Galchenkova M, Gevorkov Y, Li C, Awel S, Peck A, Barthelmess M, Schlünzen F, Lourdu Xavier P, Werner N, Andaleeb H, Ullah N, Falke S, Srinivasan V, França BA, Schwinzer M, Brognaro H, Rogers C, Melo D, Zaitseva-Doyle JJ, Knoska J, Peña-Murillo GE, Mashhour AR, Hennicke V, Fischer P, Hakanpää J, Meyer J, Gribbon P, Ellinger B, Kuzikov M, Wolf M, Beccari AR, Bourenkov G, von Stetten D, Pompidor G, Bento I, Panneerselvam S, Karpics I, Schneider TR, Garcia-Alai MM, Niebling S, Günther C, Schmidt C, Schubert R, Han H, Boger J, Monteiro DCF, Zhang L, Sun X, Pletzer-Zelgert J, Wollenhaupt J, Feiler CG, Weiss MS, Schulz EC, Mehrabi P, Karničar K, Usenik A, Loboda J, Tidow H, Chari A, Hilgenfeld R, Uetrecht C, Cox R, Zaliani A, Beck T, Rarey M, Günther S, Turk D, Hinrichs W, Chapman HN, Pearson AR, Betzel C, Meents A. (2021) X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease. Science. 2021 May 7;372(6542):642-646. doi: 10.1126/science.abf7945
Herker E, Vieyres G, Beller M, Krahmer N, Bohnert M. (2021) Lipid Droplet Contact Sites in Health and Disease. Trends Cell Biol. 2021 May;31(5):345-358. doi: 10.1016/j.tcb.2021.01.004
Jung JM, Ching W, Baumdick ME, Hofmann-Sieber H, Bosse JB, Koyro T, Möller KJ, Wegner L, Niehrs A, Russu K, Ohms M, Zhang W, Ehrhardt A, Duisters K, Spierings E, Hölzemer A, Körner C, Jansen SA, Peine S, Königs I, Lütgehetmann M, Perez D, Reinshagen K, Lindemans CA, Altfeld M, Belderbos M, Dobner T, Bunders MJ. (2021) KIR3DS1 directs NK cell-mediated protection against human adenovirus infections. Sci Immunol. 2021 Sep 17;6(63):eabe2942. doi: 10.1126/sciimmunol.abe2942
Kolbe V, Ip WH, Kieweg-Thompson L, Lang J, Gruhne J, Meyer T, Wilkens B, Schie M, Thünauer R, Schreiner S, Bertzbach LD, Rodríguez E, Dobner T. (2021) Conserved E1B-55K SUMOylation in different human adenovirus species is a potent regulator of intracellular localization. J Virol. 2021 Nov 17:JVI0083821. doi: 10.1128/JVI.00838-21
Kopicki JD, Saikia A, Niebling S, Günther C, Garcia-Alai MM, Springer S, Uetrecht C. (2021). Mapping the peptide binding groove of MHC class I. bioRxiv. doi: 10.1101/2021.08.12.455998
Krichel B, Bylapudi G, Schmidt C, Blanchet C, Schubert R, Brings L, Koehler M, Zenobi R, Svergun D, Lorenzen K, Madhugiri R, Ziebuhr J, Uetrecht C. (2021) Hallmarks of Alpha- and Betacoronavirus non-structural protein 7+8 complexes. Science advances, 7(10), eabf1004 doi: 10.1126/sciadv.abf1004
Louadi Z, Elkjaer ML, Klug M, Lio CT, Fenn A, Illes Z, Bongiovanni D, Baumbach J, Kacprowski T, List M, Tsoy O. (2021) Functional enrichment of alternative splicing events with NEASE reveals insights into tissue identity and diseases. Genome Biol 22, 327. doi: 10.1186/s13059-021-02538-1
Malhotra S, Joseph AP, Thiyagalingam J, Topf M. (2021) Assessment of protein-protein interfaces in cryo-EM derived assemblies. Nat Commun 12(1):3399 doi: 10.1038/s41467-021-23692-x
Manz Q, Tsoy O, Fenn A, Baumbach J, Völker U, List M, Kacprowski T (2021) ASimulatoR: splice-aware RNA-Seq data simulation. Bioinformatics 2021 Feb 27, btab142. doi: 10.1093/bioinformatics/btab142
Pfitzner S, Bosse JB, Hofmann-Sieber H, Flomm F, Reimer R, Dobner T, Grünewald K, Franken LE. (2021) Human Adenovirus Type 5 Infection Leads to Nuclear Envelope Destabilization and Membrane Permeability Independently of Adenovirus Death Protein. Int J Mol Sci. 2021 Dec 2;22(23):13034. doi: 10.3390/ijms222313034
Pogan R, Weiss VU, Bond K, Dülfer J, Krisp C, Lyktey N, Mueller-Guhl J, Zoratto S, Allmaier G, Jarrold MF, Munoz-Fontela C, Schlüter H, Uetrecht C. (2021) N-terminal VP1 truncations favor T=1 norovirus-like particles. Vaccines, 9:8 doi: 10.3390/vaccines9010008
Sadegh S, Skelton J, Anastasi E, Bernett J, Blumenthal DB, Galindez G, Salgado-Albarrán M, Lazareva O, Flanagan K, Cockell S, Nogales C, Casas AI, Schmidt HHHW, Baumbach J, Wipat A, Kacprowski T. (2021) Network medicine for disease module identification and drug repurposing with the NeDRex platform. Nat Commun. 2021 Nov 25;12(1):6848. doi: 10.1038/s41467-021-27138-2
Simanjuntak Y, Schamoni-Kast K, Grün A, Uetrecht C, Scaturro P (2021). Top-Down and Bottom-Up Proteomics Methods to Study RNA Virus Biology. Viruses. 2021 Apr 13;13(4):668. doi: 10.3390/v13040668
Tegtmeyer B, Vieyres G, Todt D, Lauber C, Ginkel C, Engelmann M, Herrmann M, Pfaller CK, Vondran FWR, Broering R, Vafadarnejad E, Saliba AE, Puff C, Baumgärtner W, Miskey C, Ivics Z, Steinmann E, Pietschmann T, Brown RJP. (2021) Initial HCV infection of adult hepatocytes triggers a temporally structured transcriptional program containing diverse pro- and anti-viral elements. J Virol. 2021 Mar 3;95(10):e00245-21. doi: 10.1128/JVI.00245-21
Vieyres G. (2021) PicPreview and PicSummary: Two Timesaving Plugins for the Fluorescence Microscopist. Cells, 2021 Apr 8;10(4):846. doi: 10.3390/cells10040846

2020

Alio I, Gudzuhn M, Pérez García P, Danso D, Schoelmerich M, Mamat U, Schaible UE, Steinmann J, Yero D, Gibert I, Kohl TA, Niemann S, Gröschel MI, Haerdter J, Hackl T, Vollstedt C, Bömeke M, Egelkamp R, Daniel R, Poehlein A, Streit WR. (2020) Phenotypic and transcriptomic analysis of seven clinical Stenotrophomonas maltophilia isolates identify a small set of shared and commonly regulated genes involved in biofilm lifestyle. Appl Environ Microbiol. 2020 Oct 23:AEM.02038-20. doi: 10.1128/AEM.02038-20.
Brown RJP, Tegtmeyer B, Sheldon J, Khera T, Anggakusuma, Todt D, Vieyres G, Weller R, Joecks S, Zhang Y, Sake S, Bankwitz D, Welsch K, Ginkel C, Engelmann M, Gerold G, Steinmann E, Yuan Q, Ott M, Vondran FWR, Krey T, Ströh LJ, Miskey C, Ivics Z, Herder V, Baumgärtner W, Lauber C, Seifert M, Tarr AW, McClure CP, Randall G, Baktash Y, Ploss A, Thi VLD, Michailidis E, Saeed M, Verhoye L, Meuleman P, Goedecke N, Wirth D, Rice CM, Pietschmann T. (2020) Liver-expressed Cd302 and Cr1l limit hepatitis C virus cross-species transmission to mice. Sci Adv. 2020 Nov 4;6(45):eabd3233. doi: 10.1126/sciadv.abd3233
Gröschel MI, Meehan CJ, Barilar I, Diricks M, Gonzaga A, Steglich M, Conchillo-Solé O, Scherer IC, Mamat U, Luz CF, De Bruyne K, Utpatel C, Yero D, Gibert I, Daura X, Kampmeier S, Rahman NA, Kresken M, van der Werf TS, Alio I, Streit WR, Zhou K, Schwartz T, Rossen JWA, Farhat MR, Schaible UE, Nübel U, Rupp J, Steinmann J, Niemann S, Kohl TA. (2020) The phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist Stenotrophomonas maltophilia. Nat Commun. 2020;11(1):2044. doi: 10.1038/s41467-020-15123-0
Joseph AP, Lagerstedt I, Jakobi A, Burnley T, Patwardhan A, Topf M, Winn M. (2020) Comparing Cryo-EM Reconstructions and Validating Atomic Model Fit Using Difference Maps. J Chem Inf Model 60(5):2552–2560. doi: 10.1021/acs.jcim.9b01103
Krichel B, Falke S, Hilgenfeld R, Redecke L, Uetrecht C. (2020) Processing of the SARS-CoV pp1a/ab nsp7-10 region. Biochem J, 477(5):1009-1019. doi: 10.1042/BCJ20200029
Louadi Z, Yuan K, Gress A, Tsoy O, Kalinina O, Baumbach J, Kacprowski T, List M (2020) DIGGER: Exploring the functional role of alternative splicing in protein interactions. Nucleic Acids Res. 2020 Sep 25:gkaa768 doi: 10.1093/nar/gkaa768
Pfitzner S, Hofmann-Sieber H, Bosse JB, Franken LE, Grünewald K, Dobner T (2020) Fluorescent protein tagging of adenoviral proteins pV and pIX reveals ‘late virion accumulation compartment’. PLOS Pathogens 16(6): e1008588. doi: 10.1371/journal.ppat.1008588
Sinnott M, Malhotra S, Madhusudhan MS, Thalassinos K, Topf M. (2020) Combining Information from Crosslinks and Monolinks in the Modeling of Protein Structures. Structure 28(9):1061-1070.e3. doi: 10.1016/j.str.2020.05.012
Vollmer B, Pražák V, Vasishtan D, Jefferys EE , Hernandez-Duran A, Vallbracht M, Klupp B, Mettenleiter TC, Backovic M, Rey FA, Topf M, Grünewald K (2020). The prefusion structure of herpes simplex virus glycoprotein B. Science Advances. eabc1726. doi: 10.1126/sciadv.abc1726

Prof. Dr. Kay Grünewald

Dr. Frederike Ahr

Publikationen

2022

2021

2020

Leibniz-WissenschaftsCampus InterACt

Sprecher des Campus

Koordinatorin des Campus

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