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Projekte der zweiten Förderphase

Im Rahmen des Leibniz-WissenschaftsCampus InterACt werden verschiedene Projekte zur Thematik „Integrative Analyse von Pathogen-induzierten Kompartimenten“ bearbeitet. Diese sind typischerweise als Zusammenarbeit verschiedener lokaler Arbeitsgruppen unter Vernetzung verschiedener Kernkompetenzen konzipiert. Nachfolgend sind die Projekte der zwei Förderphasen angegeben.

Comprehensive proteomic analysis of human cytomegalovirus replication compartments

Brune, Schlüter, Bosse,Topf

Structural-functional characterization of the adenoviral DNA binding protein, a key player in viral replication center formation, viral genome replication and production of viral progeny

Dobner, Witt, Alai, Pearson

Membrane dynamics during rhoptry secretion of the malaria parasite

Gilberger, Grünewald

Herpesvirus genome injection at nuclear core complexes

Grünewald, Baumbach, Kosinski, Thünauer

Formation and dynamics of latent herpesvirus episome compartments

Grundhoff, Grünewald, Bosse, Kurtz

Organization of intracellular membrane in Mycobacteria infected cells

Gutsmann, Topf, Homolka, Dallenga, Schwudke, Schaible, Grünewald, Thünauer

Selective replication of viral genomes through nucleated phase separation

Meier, Bosse, Brune, Hoth, Rosenthal, Grundhoff

The role of lipid droplet biogenesis and metabolism in mycobacterial and viral infections

Reiling, Vieyres, Streit, Thünauer, Gutsmann, Schwudke

Dynamic changes of the interactions during transition from viral genome replication to RNP recruitment and budding in Lassa virus infection

Rosenthal, Topf, Uetrecht, Kehr, Grünewald

Deciphering the multiple roles of Dengue virus non-structural protein 1 in different intracellular compartments

Scaturro, Thünauer, Topf

Employing bacteriophages as a combat tool against pathogenic multispecies biofilms

Streit, Schromm, Rohde, Sondermann, Schaible, Topf

Spatially-resolved bystander effects in viral infections

Vieyres, Fischer, Baumbach, Thünauer, Tsoy

Projekte der ersten Förderphase

Herpesvirus genome injection at nuclear core complexes

Bosse, Meier, Grünewald, Kosinski

funded by the BWFGB as part of the Landesforschungsförderung project Cellular Mechanism of Infections (CeMeIn)

Intracellular membrane organization in Mycobacterium infected cells

Gutsmann, Schaible, Grünewald, Gilberger

Lipid Droplets in infection

Herker, Bosse, Schlüter, Schaible

Viral replication compartments as phase-separated intranuclear domains

Brune (herpes), Dobner (adeno), Grünewald, Meier, Bosse, Schlüter, Maison

funded by the LIV Strategic Incentive Programme

Mechanisms of nucleic acid-protein interactions in viral particle assembly

Uetrecht, Bosse, Pearson, Dobner, Grünewald, Rarey, Twarock

funded by the BWFGB as part of the Landesforschungsförderung project Cellular Mechanism of Infections (CeMeIn)

Flexibility of viral induced nuclear egress coat

Grünewald, Rarey, Bosse, Kosinski

Disassembly of the inner membrane complex of Plasmodium falciparum

Gilberger, Grünewald

funded by the CSSB Cooperation and Integration Fund

Dynamics and function of infection compartments and defense-induced cellular re-organizations in plant cells

Hoth, Kehr, Schnittger, Reumann, Meier, Bosse

funded by the BWFGB as part of the Landesforschungsförderung project Cellular Mechanism of Infections (CeMeIn)

Phage spread shaping nanostructures of biofilms

Streit, Schaible, Schlüter, Dobner, Ignatova

Computational modelling of virus capsid formation

Grünewald, Topf, Rarey, Uetrecht, Pearson, Baumbach

funded by the BWFGB as part of the Center for Data and Computing in Natural Science (CDCS) - Cross Disciplinary Lab 3

Integrative analysis of biomacromolecular interactions

Baumbach, Rarey, Uetrecht, Pearson, Grünewald, Topf

funded by the BWFGB as part of the Center for Data and Computing in Natural Science (CDCS) - Cross Disciplinary Lab 3

Transport form and interactome of plant RNA viruses

Kehr, Uetrecht, Grünewald

funded by the BWFGB as part of the Landesforschungsförderung project Cellular Mechanism of Infections (CeMeIn)

Peroxisome-mediated neutralization of antiviral defense strategies

Reumann, Dobner, Kehr

funded by the BWFGB as part of the Landesforschungsförderung project Cellular Mechanism of Infections (CeMeIn)

Virus-host interactions essential for Lassa virus genome replication and transcription

Rosenthal, Kosinski

funded by the DFG

Spatiotemporal coordination of herpesvirus secondary envelopment

Bosse, Grünewald, Topf, Reimer, Thalassinos

funded by Wellcome Trust