The Leibniz ScienceCampus InterACt connects the various research groups and infrastructures in the Hamburg Metropolitan region on the topic "Integrative Analysis of pathogen-induced Compartments". The research groups and infrastructures involved in the network and their research contributions to InterACt are listed below.
Computational Systems Biology
Prof. Dr. Jan Baumbach
Universität Hamburg, Department of Informatics, ZBH - Center for Bioinformatics
Bioinformatics | Computational Biology | Systems Medicine | Network Medicine | Biomarker Discovery & Validation | Precision Medicine | Computational Biotechnology | Big Data Analytics | Machine Learning | Combinatorial Optimization | Privacy by Design
Hannover Medical School, Institute of Virology, RESIST Cluster of Excellence | Centre of Structural Systems Biology | Leibniz Institute for Experimental Virology (HPI), RESIST guest group
molecular biology, biochemistry and cell biology of plant autoimmunity and defense | function of plasma membrane-associated Ubiquitin ligases in vesicle tethering | meristem function and DNA damage response in plant development
protein translation and folding | translation control | systems biology of translation | translation-related pathologies and infections | tissue-specificity of translation and various pathologies | RNA | ribosomes | aging
organic synthesis and coordination chemistry | Tumor targeting (prostate cancer); metal-based reagents for MRI, PET and SPECT | antibacterial surfaces (metals and plastics) for implant medicine and clinical hygiene | development of chemical corrosion inhibitors | siderophore analogues for biomedical applications
cheminformatics | structure-based molecular design | structuralbioinformatics | development of computational methods for life science | visual analytics of chemical data | machine learning and data mining of chemical structures and molecular complexes | navigation in large chemical spaces
confocal microscopy | TIRF | single molecule imaging techniques | functional imaging of living cells | 3D electron microscopy | TEM / SEM | correlative light and electron microscopy | (cryo)-ultramicrotomy | microtomy | cryo-preparation | histology | negative staining of particles | image analysis
host-pathogen interactions in tuberculosis | mycobacterial intracellular niche as determinant for transmission, immunity, pathogenesis, drug efficacy | translational research on host-directed-therapy and nanocarrier-based drug delivery | lung microbiota, stenotrophomonas maltophilia
analysis and modelling of pathogen-related transport processes in biological systems | algorithms for the analysis of complex multiscale image data (e.g. live-cell imaging) | machine learning supported feature analysis for biological images | user training, tool development and support for image analysis tasks
entry and progression through meiosis | organization of meiotic chromosomes | cell biology of meiocytes | DNA damage response and homologous recombination | live cell imaging
functional metagenomics in the search for new biocatalysts | microbial plastics degradadtion | marine biotechnology | microbial biofilms: analytics, architecture and omics | cell-cell communication in bacteria
confocal microscopy | TIRF | single molecule imaging techniques | functional imaging of living cells | 3D electron microscopy | TEM / SEM | correlative light and electron microscopy | (cryo)-ultramicrotomy | microtomy | cryo-preparation | histology | negative staining of particles | image analysis
mathematical and computational modelling of virus structure, assembly mechanisms and evolution | intra- and inter-cellular models of infection dynamics | bioinformatics of viral genomes | antiviral therapy | virus nanotechnology
viral capsid assembly as well as viral replication complexes and the underlying protein structural dynamics | development of native mass spectrometry for higher resolution structural proteomics and single particle imaging at X-ray free-electron lasers | hydrogen/deuterium exchange mass spectrometry