Research Groups and Infrastructures

The Leibniz ScienceCampus InterACt connects the various research groups and infrastructures in the Hamburg Metropolitan region on the topic "Integrative Analysis of pathogen-induced Compartments". The research groups and infrastructures involved in the network and their research contributions to InterACt are listed below.
Structural biology of infection and inflammation, Crystallography

Prof. Dr. Christian Betzel

Universität Hamburg, Department of Chemistry
Research interests and expertise
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Quantitative Virology

Prof. Dr. Jens Bernhard Bosse

Hannover Medical School, Institute of Virology, RESIST Cluster of Excellence | Centre of Structural Systems Biology | Heinrich Pette Institute, Leibniz Institute for Experimental Virology,  RESIST guest group
Research interests and expertise
spatiotemporal control of virus morphogenesis| dynamics and kinetics of molecular machines| live-cell Imaging| light-sheet microscopy| CLEM
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Virus-Host Interaction

Prof. Dr. Wolfram Brune

Heinrich Pette Institute, Leibniz Institute for Experimental Virology | Universität Hamburg, Department of Chemistry
Research interests and expertise
virus-host interaction | herpesvirus | cytomegalovirus | replication compartments | cell death | apoptosis | necroptosis | pyroptosis | autophagy | macrophage | innate immunity | signaling | inflammatory cytokines | interferon | ER stress | unfolded protein response | UPR | cell fusion | syncytium | antivirals
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Viral Transformation

Prof. Dr. Thomas Dobner

Heinrich Pette Institute, Leibniz Institute for Experimental Virology | Universität Hamburg, Department of Biology
Research interests and expertise
viral oncogenesis | intrinsic immunity | SUMOylation | nuclear domains | viral replication compartments | antiviral targets
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Cell Biology of Human Parasites

Prof. Dr. Tim Gilberger

Bernhard Nocht Institute for Tropical Medicine| Centre of Structural Systems Biology | Universität Hamburg, Department of Biology
Research interests and expertise
cell biology of human parasites | malaria | proliferation strategies in erythrocytes | immunevasion | pathogenicity factors | dynamic of intracellular compartments | protein networks | Post-translational modifications | structure-function analysis | reverse genetics | phenotyping | live and high-resolution microscopy
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Structural Cell Biology of Viruses

Prof. Dr. Kay Grünewald

Heinrich Pette Institute, Leibniz Institute for Experimental Virology | Centre of Structural Systems Biology | Universität Hamburg, Department of Chemistry
Research interests and expertise
structural cell biology | virus-host interactions (herpes-, adeno- and retroviruses) | protein-protein interaction networks | integrative structural biology | cryo electron microscopy/tomography | correlative cryo microscopy | image analysis and data processing | molecular dynamics and visualization
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Biophysics

Prof. Dr. Thomas Gutsmann

Research Center Borstel, Leibniz Lung Center
Research interests and expertise
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Institute for Virology

Prof. Dr. Eva Herker

Universität Marburg
Research interests and expertise
virus-host interactions | Hepatitis C virus | flaviviruses | lipid droplets | lipid metabolism | organelle interactions | live cell microscopy | electron microscopy | endogenous retroelements
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Molecular Plant Physiology

Prof. Dr. Stefan Hoth

Universität Hamburg, Department of Biology
Research interests and expertise
molecular biology, biochemistry and cell biology of plant autoimmunity and defense | function of plasma membrane-associated Ubiquitin ligases in vesicle tethering | meristem function and DNA damage response in plant development
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RNA Biochemsitry and Molecular Biology

Prof. Dr. Zoya Ignatova

Universität Hamburg, Department of Chemistry
Research interests and expertise
protein translation and folding | translation control | systems biology of translation | translation-related pathologies and infections | tissue-specificity of translation and various pathologies | RNA | ribosomes | aging
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Molecular Plant Genetics

Prof. Dr. Julia Kehr

Universität Hamburg, Department of Biology
Research interests and expertise
plants| phloem| long distance transport| signaling| RNA binding proteins| ribonucleoprotein complexes| virus infection| mass spectrometry
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Integrative modelling of infection cycles

Dr. Jan Kosinski

Centre of Structural Systems Biology CSSB | EMBL
Research interests and expertise
infection cycles of pathogens | host-pathogen interactions | macromolecular complexes | influenza A virus | nuclear pore complexes | proteomics | imaging | computational modeling
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Pharmaceutical and Medicinal Chemistry

Prof. Dr. Wolfgang Maison

Universität Hamburg, Department of Chemistry
Research interests and expertise
organic synthesis and coordination chemistry | Tumor targeting (prostate cancer); metal-based reagents for MRI, PET and SPECT | antibacterial surfaces (metals and plastics) for implant medicine and clinical hygiene | development of chemical corrosion inhibitors | siderophore analogues for biomedical applications
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Organic Chemistry, Medicinal Chemistry  and Chemical Biology

Prof. Dr. Chris Meier

Universität Hamburg, Department of Chemistry
Research interests and expertise
organic and medicinal chemistry | chemical Biology | antiviral drug discovery (Virus families: Bunya viruses, Retroviruses, Hepatitis, filo-virues) | small molecule inhibitors | nucleos(t)die chemistry | pronucleotides | lipophilic adenosine second messengers | RNA-polymerases | structure biology with polymerases and the enzyme DHODH
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Experimental Biophysics

Prof. Dr. Arwen Pearson

Universität Hamburg, Fachbereich Physik | Center for Ultrafast Imaging CUI | Center for Free-electron Science CFEL
Research interests and expertise
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Computational Molecular Design

Prof. Dr. Matthias Rarey

Universität Hamburg, Department of Informatics, ZBH - Center for Bioinformatics
Research interests and expertise
cheminformatics | structure-based molecular design | structuralbioinformatics | development of computational methods for life science | visual analytics of chemical data | machine learning and data mining of chemical structures and molecular complexes | navigation in large chemical spaces
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Microscopy and Image Analysis technology platform

Dr. Rudolph Reimer

Heinrich Pette Institute, Leibniz Institute for Experimental Virology
Research interests and expertise
confocal microscopy | TIRF | single molecule imaging techniques | functional imaging of living cells | 3D electron microscopy | TEM / SEM | correlative light and electron microscopy | (cryo)-ultramicrotomy | microtomy | cryo-preparation | histology | negative staining of particles | image analysis
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Plant Biochemistry and Infection Biology

Prof. Dr. Sigrun Reumann

Universität Hamburg, Department of Biology
Research interests and expertise
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Structural Virology

Dr. Maria Rosenthal

Bernhard Nocht Institute for Tropical Medicine
Research interests and expertise
bunyaviruses | Lassa virus | Rift Valley fever virus | genome replication and transcription | molecular mechanism | L protein | viral polymerase | protein-protein interaction | protein-RNA interaction | virus-host interaction | functional assays | structural biology | biochemistry | molecular biology | reverse genetics
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Cellular Microbiology

Prof. Dr. Ulrich Schaible

Research Center Borstel, Leibniz Lung Center
Research interests and expertise
host-pathogen interactions in tuberculosis | mycobacterial intracellular niche as determinant for transmission, immunity, pathogenesis, drug efficacy | translational research on host-directed-therapy and nanocarrier-based drug delivery | lung microbiota, stenotrophomonas maltophilia
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Image Processing Specialist

Marcel Schie

Heinrich Pette Institute, Leibniz Institute for Experimental Virology
Research interests and expertise
analysis and modelling of pathogen-related transport processes in biological systems | algorithms for the analysis of complex multiscale image data (e.g. live-cell imaging) | machine learning supported feature analysis for biological images | user training, tool development and support for image analysis tasks
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Mass Spectrometric Proteomics

Prof. Dr. Hartmut Schlüter

Medical Center Hamburg-Eppendorf, Universität Hamburg, Department of Chemistry
Research interests and expertise
differential quantitative mass spectrometry-based proteomics | labeling based quantification: SILAC, TMT | labeling-free quantification: DIA, DDA, SRM | systems biology | protein-protein interactions | pathway analysis | targeted proteomics | mass spectrometric imaging | proteoforms | glycans | glycoproteomics | phosphoproteomics
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Developmental Biology

Prof. Dr. Arp Schnittger

Universität Hamburg, Department of Biology
Research interests and expertise
entry and progression through meiosis | organization of meiotic chromosomes | cell biology of meiocytes | DNA damage response and homologous recombination | live cell imaging
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Microbiology and Biotechnology

Prof. Dr. Wolgang Streit

Universität Hamburg, Department of Biology
Research interests and expertise
functional metagenomics in the search for new biocatalysts | microbial plastics degradadtion | marine biotechnology | microbial biofilms: analytics, architecture and omics | cell-cell communication in bacteria
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Mathematics and Computational Virology

Prof. Dr. Reidun Twarock

University of York
Research interests and expertise
mathematical and computational modelling of virus structure, assembly mechanisms and evolution | intra- and inter-cellular models of infection dynamics | bioinformatics of viral genomes | antiviral therapy | virus nanotechnology
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Dynamic of Viral Structures

Dr. Charlotte Uetrecht

Heinrich Pette Institute, Leibniz Institute for Experimental Virology | European XFEL GmbH | associated Centre of Structural Systems Biology
Research interests and expertise
viral capsid assembly as well as viral replication complexes and the underlying protein structural dynamics | development of native mass spectrometry for higher resolution structural proteomics and single particle imaging at X-ray free-electron lasers | hydrogen/deuterium exchange mass spectrometry
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Cell Biology of RNA Viruses

Dr. Gabrielle Vieyers

Heinrich Pette Institute, Leibniz Institute for Experimental Virology
Research interests and expertise
RNA viruses| Hepatitis C virus| lipid droplets| virus replication| assembly and release| cell determinants of plus-strand RNA virus replication| innate immunity| cell biology| Confocal microscopy| automatized image analysis
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Integrative Virology

N.N.

Heinrich Pette Institute, Leibniz Institute for Experimental Virology
Research interests and expertise
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Computational Systems Biology

N.N.

Universität Hamburg, Department of Informatics, ZBH - Center for Bioinformatics
Research interests and expertise
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Infection biology

N.N.

Universität Hamburg, Department of Biology
Research interests and expertise
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Leibniz ScienceCampus InterACt

c/o Heinrich Pette Institute,
Leibniz Institute for Experimental Virology

Building N63
Martinistraße 52
20251 Hamburg

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Campus Speaker

Prof. Dr. Kay Grünewald

Campus Coordinator

Dr. Frederike Ahr

Partner

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