Research Groups and Infrastructures

Bioinformatics | Computational Biology | Systems Medicine | Network Medicine | Biomarker Discovery & Validation | Precision Medicine | Computational Biotechnology | Big Data Analytics | Machine Learning | Combinatorial Optimization | Privacy by Design

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spatiotemporal control of virus morphogenesis| dynamics and kinetics of molecular machines| live-cell Imaging| light-sheet microscopy| CLEM

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virus-host interaction | herpesvirus | cytomegalovirus | replication compartments | cell death | apoptosis | necroptosis | pyroptosis | autophagy | macrophage | innate immunity | signaling | inflammatory cytokines | interferon | ER stress | unfolded protein response | UPR | cell fusion | syncytium | antivirals

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viral oncogenesis | intrinsic immunity | SUMOylation | nuclear domains | viral replication compartments | antiviral targets

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cell biology of human parasites | malaria | proliferation strategies in erythrocytes | immunevasion | pathogenicity factors | dynamic of intracellular compartments | protein networks | Post-translational modifications | structure-function analysis | reverse genetics | phenotyping | live and high-resolution microscopy

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structural cell biology | virus-host interactions (herpes-, adeno- and retroviruses) | protein-protein interaction networks | integrative structural biology | cryo electron microscopy/tomography | correlative cryo microscopy | image analysis and data processing | molecular dynamics and visualization

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virus-host interactions | Hepatitis C virus | flaviviruses | lipid droplets | lipid metabolism | organelle interactions | live cell microscopy | electron microscopy | endogenous retroelements

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molecular biology, biochemistry and cell biology of plant autoimmunity and defense | function of plasma membrane-associated Ubiquitin ligases in vesicle tethering | meristem function and DNA damage response in plant development

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protein translation and folding | translation control | systems biology of translation | translation-related pathologies and infections | tissue-specificity of translation and various pathologies | RNA | ribosomes | aging

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cryo super-resolution fluorescence microscopy | cryo-CLEM | in-resin super-resolution CLEM | photo-physics under cryo conditions | optical engineering |cryogenic engineering

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plants| phloem| long distance transport| signaling| RNA binding proteins| ribonucleoprotein complexes| virus infection| mass spectrometry

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infection cycles of pathogens | host-pathogen interactions | macromolecular complexes | influenza A virus | nuclear pore complexes | proteomics | imaging | computational modeling

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Evolutionary genetics and genomics | Host-pathogen coevolution | antigen presentation and recognition | bioinformatics

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Phagocytosis and intracellular processing of bacteria | Spirochetes (Borrelia burgdorferi) | Primary human macrophages | Cytoskeleton (actin, tubulin) | Intracellular transport | Membrane dynamics | Live cell and high resolution microscopy

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organic synthesis and coordination chemistry | Tumor targeting (prostate cancer); metal-based reagents for MRI, PET and SPECT | antibacterial surfaces (metals and plastics) for implant medicine and clinical hygiene | development of chemical corrosion inhibitors | siderophore analogues for biomedical applications

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organic and medicinal chemistry | chemical Biology | antiviral drug discovery (Virus families: Bunya viruses, Retroviruses, Hepatitis, filo-virues) | small molecule inhibitors | nucleos(t)die chemistry | pronucleotides | lipophilic adenosine second messengers | RNA-polymerases | structure biology with polymerases and the enzyme DHODH

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cheminformatics | structure-based molecular design | structuralbioinformatics | development of computational methods for life science | visual analytics of chemical data | machine learning and data mining of chemical structures and molecular complexes | navigation in large chemical spaces

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confocal microscopy | TIRF | single molecule imaging techniques | functional imaging of living cells | 3D electron microscopy | TEM / SEM | correlative light and electron microscopy | (cryo)-ultramicrotomy | microtomy | cryo-preparation | histology | negative staining of particles | image analysis

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bunyaviruses | Lassa virus | Rift Valley fever virus | genome replication and transcription | molecular mechanism | L protein | viral polymerase | protein-protein interaction | protein-RNA interaction | virus-host interaction | functional assays | structural biology | biochemistry | molecular biology | reverse genetics

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Arboviruses | RNA viruses| Flaviviruses| Bottom-up Mass-spectrometry| virus replication| assembly and release| cellular determinants of plus-strand RNA virus replication| Systems Biology| Proteomics| Post-translational modifications| mosquitoes cell-virus interactions

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host-pathogen interactions in tuberculosis | mycobacterial intracellular niche as determinant for transmission, immunity, pathogenesis, drug efficacy | translational research on host-directed-therapy and nanocarrier-based drug delivery | lung microbiota, stenotrophomonas maltophilia

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analysis and modelling of pathogen-related transport processes in biological systems | algorithms for the analysis of complex multiscale image data (e.g. live-cell imaging) | machine learning supported feature analysis for biological images | user training, tool development and support for image analysis tasks

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differential quantitative mass spectrometry-based proteomics | labeling based quantification: SILAC, TMT | labeling-free quantification: DIA, DDA, SRM | systems biology | protein-protein interactions | pathway analysis | targeted proteomics | mass spectrometric imaging | proteoforms | glycans | glycoproteomics | phosphoproteomics

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entry and progression through meiosis | organization of meiotic chromosomes | cell biology of meiocytes | DNA damage response and homologous recombination | live cell imaging

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cryo electron-microscopy | host-pathogen interaction | molecular and cellular electron cryo-tomography | Cryo-SPA | FIB / SEM | correlative light and electron microscopy | cryo-specimen preparation | negative staining of particles | image analysis | training | method development

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functional metagenomics in the search for new biocatalysts | microbial plastics degradadtion | marine biotechnology | microbial biofilms: analytics, architecture and omics | cell-cell communication in bacteria

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confocal microscopy | TIRF | single molecule imaging techniques | functional imaging of living cells | 3D electron microscopy | TEM / SEM | correlative light and electron microscopy | (cryo)-ultramicrotomy | microtomy | cryo-preparation | histology | negative staining of particles | image analysis

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Computational structural biology | macromolecular assemblies | viral protein interaction networks | cryo electron microscopy | cryo EM validation | image processing | density fitting | integrative modelling | molecular simulations | molecular docking

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mathematical and computational modelling of virus structure, assembly mechanisms and evolution | intra- and inter-cellular models of infection dynamics | bioinformatics of viral genomes | antiviral therapy | virus nanotechnology

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viral capsid assembly as well as viral replication complexes and the underlying protein structural dynamics | development of native mass spectrometry for higher resolution structural proteomics and single particle imaging at X-ray free-electron lasers | hydrogen/deuterium exchange mass spectrometry

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RNA viruses| Hepatitis C virus| lipid droplets| virus replication| assembly and release| cell determinants of plus-strand RNA virus replication| innate immunity| cell biology| Confocal microscopy| automatized image analysis

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Cloning and mutagenesis | R2/S2 cultivation of prokaryotic and eukaryotic cells | Transformation of prokaryotes | Transfection of eukaryotes | High-throughput heterologous expression screening in plate format | Recombinant expression in E. coli, insect cells and mammalian cells | Cell harvest and cell lysis | Ultracentrifugation and cell membrane isolation | Protein purification | Development, optimisation & automation of protein purification protocols | Biophysical & biochemical characterisation | E. coli strain collection | Expression vector collection | NEB freezer

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