Integrative Virology

Head: Prof. Dr. Maya Topf

The attachment of viruses to the cell, their entry, uncoating, biosynthesis, assembly, and release, all involve the formation of protein-protein interactions between the viral proteins themselves and between viral and host proteins. Thus, it is of great biomedical interest to understand the structure of complexes formed by these interactions, with the aim of designing antiviral therapies that can block them, or alternatively re-engineer viruses for use as targeted delivery vehicles. In recent years, the use of integrative, information-driven approaches for modeling structures of complexes such as those formed by viruses in cells has been increasing in popularity. The Research Department of Integrative Virology applies an integrated systems biology approach that combines computational and experimental methods specifically designed to achieve a comprehensive picture of viral infections, with specific focus on cryoEM, mass spectrometry-based proteomics and bioinformatics.

Leibniz ScienceCampus InterACt

c/o Heinrich Pette Institute,
Leibniz Institute for Experimental Virology

Building N63
Martinistraße 52
20251 Hamburg

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Campus Speaker

Prof. Dr. Kay Grünewald

Campus Coordinator

Dr. Frederike Ahr

Partner

Logo Heinrich-Pette-Institut
Logo Universität Hamburg
Logo Leibniz Center Infection
Logo Bernhard-Nocht-Institut
Logo Forschungszentrum Borstel
Logo Hamburg Behörde für Wissenschaft und Forschung
Logo Leibniz Gemeinschaft